Atherosclerosis is a disease in which plaque builds up inside arteries. Arteries are blood vessels that carry oxygen-rich blood to heart and other parts of your body.
Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood. Over time, plaque hardens and narrows arteries. This limits the flow of oxygen-rich blood to organs and other parts of your body.
Atherosclerosis can lead to serious problems, including heart attack, stroke, or even death.
References:
http://www.nhlbi.nih.gov/health/health-topics/topics/atherosclerosis
http://www.nhlbi.nih.gov/health/health-topics/topics/atherosclerosis/causes
http://www.nhlbi.nih.gov/health/health-topics/topics/atherosclerosis/atrisk
http://www.nhlbi.nih.gov/health/health-topics/topics/atherosclerosis/signs
http://www.nhlbi.nih.gov/health/health-topics/topics/atherosclerosis/diagnosis
http://www.nhlbi.nih.gov/health/health-topics/topics/atherosclerosis/treatment
http://www.nhlbi.nih.gov/health/health-topics/topics/atherosclerosis/prevention
Atherosclerosis usually
doesn't cause signs and symptoms until it severely narrows or totally blocks an
artery. Many people don't know they have the disease until they have a medical
emergency, such as heart attack or stroke.
Some people may have
signs and symptoms of the disease. Signs and symptoms will depend on which
arteries are affected.
Coronary Arteries
The coronary arteries
supply oxygen-rich blood to heart. If plaque narrows or blocks
these arteries (a disease called coronary heart disease, or CHD), it may
lead to angina. Angina is chest pain or discomfort that occurs
when heart muscle doesn't get enough oxygen-rich blood.
Angina may feel like
pressure or squeezing in chest. Pain may also be felt in shoulders,
arms, neck, jaw, or back. Angina pain may even feel like indigestion. The pain
tends to get worse with activity and go away with rest. Emotional stress also can
trigger the pain.
Other symptoms of CHD are
shortness of breath and arrhythmias Arrhythmias are problems with the
rate or rhythm of the heartbeat.
Plaque also can form in
the heart's smallest arteries. This disease is called coronary
microvascular disease (MVD). Symptoms of coronary MVD include angina,
shortness of breath, sleep problems, fatigue (tiredness), and lack of energy.
Carotid Arteries
The carotid arteries
supply oxygen-rich blood to brain. If plaque narrows or blocks
these arteries (a disease called carotid artery disease), one may have
symptoms of stroke. These symptoms may include:
·
Sudden
weakness
·
Paralysis
(an inability to move) or numbness of the face, arms, or legs, especially on
one side of the body
·
Confusion
·
Trouble
speaking or understanding speech
·
Trouble
seeing in one or both eyes
·
Difficulty
in breathing
·
Dizziness,
trouble walking, loss of balance or coordination, and unexplained falls
·
Loss
of consciousness
·
Sudden
and severe headache
Peripheral Arteries
Plaque also can build up
in the major arteries that supply oxygen-rich blood to the legs, arms, and
pelvis (a disease called peripheral artery disease).
If these major arteries
are narrowed or blocked, you may have numbness, pain, and sometimes dangerous
infections.
Renal Arteries
The renal arteries supply
oxygen-rich blood to kidneys. If plaque builds up in these
arteries, one may develop chronic kidney disease. Over time, chronic
kidney disease causes a slow loss of kidney function.
Early kidney disease
often has no signs or symptoms. As the disease gets worse, it can cause
tiredness, changes in how you urinate (more often or less often), loss of
appetite, nausea (feeling sick to the stomach), swelling in the hands or feet,
itchiness or numbness and trouble concentrating.